Loss of libido, impotence, diarrhea, nausea, vomiting. The incidence of these adverse events, with the exception of diarrhea (more pronounced when used in combination with flutamide), the same as monotherapy what is winstrol agonists. Less frequently: gynecomastia, anemia, leukopenia, thrombocytopenia, anorexia, edema, symptoms of neuromuscular disorders, shortness of urination, increased blood pressure and side effects of the central nervous system (drowsiness, depression, confusion, anxiety, neurosis). rare: respiratory failure, liver failure, hepatitis, cholestatic jaundice, hepatic necrosis, hepatic encephalopathy, increased light sensitivity, methemoglobinemia.
In case of overdose, if the patient is conscious and without spontaneous vomiting, induce vomiting. It is necessary to apply symptomatic therapy with continuous monitoring of patients, and vital functions.Due to the high degree of plasma protein connection hemodialysis practically ineffective.
Interaction with other drugs
In view of the possible increase in the anticoagulant action, while the use of warfarin and flutamide, the dose of the anticoagulant should be adjusted under the control of prothrombin time.
Avoid co-administration of flutamide with other hepatotoxic drugs, and alcohol.
On the background of the simultaneous reception of theophylline and flutamide marked increase in the level of theophylline in the blood, possibly due to the presence of common pathway in these preparations.
Pliva what is winstrol should be under the control of serum liver enzymes (1 time per month during the first 4 months and then on a regular basis).
In case of increase in liver enzymes in 2-3 times compared with the upper limit of the normal range and / or jaundice in the absence of liver metastases application flutamide Pliva should be discontinued.
Patients should receive the recommendation immediately consult a doctor when the first symptoms of liver problems such as itchy skin, dark urine, nausea, vomiting, persistent loss of appetite, yellowness of the skin what is winstrol sheets or sclera, pain in the right upper quadrant, or flu-like symptoms.
in patients not undergoing surgical or medical castration, during long-term treatment should be carried out analysis of spermatogenesis. Receiving flutamide can lead to higher levels of testosterone and estradiol in the blood, in connection with possible fluid retention. Particular attention should be given to patients with cardiovascular disease, also prone to edema.