The incidence of side effects and their severity are most pronounced at the beginning of treatment, reduced to the extent of continued therapy. From the nervous system: extrapyramidal disorder, parkinsonism, tremor, akathisia, dystonia, dyskinesia, speech disorder; Infrequent – dizziness, rarely – tardive dystonia. From the mental activity: depression, insomnia, agitation; rare – aggression. On the part of the cardiovascular system: orthostatic hypotension, tachycardia. From the side of hematopoiesis: rarely – granulocytopenia, agranulocytosis (more likely between 4 and 10 weeks of treatment), leukopenia, hemolytic anemia.
From what does winstrol do the side of view: oculogyric crisis, clouding of the cornea and / or lens with possible visual impairment, accommodation paresis; rare – disturbance of accommodation.From the digestive system: excessive salivation, dysphagia (swallowing disorder), cholestatic jaundice (more likely between 2 and 4 weeks of treatment); rarely – constipation. Disorders of metabolism and nutrition disorders: rarely – decreased appetite. On the part of the endocrine system: galactorrhea, gynecomastia, dysmenorrhea, impotence, decreased libido, increased appetite, weight gain, increased sweating, flushing, changes in carbohydrate metabolism. Urinary systems: urinary retention. On the part of the body as a whole: fatigue, asthenia. Allergic reactions: seldom – skin rash, dermatitis, photosensitivity. Local reactions: rarely – erythema, edema, inflammation, or abscess.
There is evidence of development of neuroleptic malignant syndrome. The main symptoms are hyperthermia, muscle rigidity, and impaired consciousness, combined with dysfunction of the autonomic nervous system (labile blood pressure, tachycardia, sweating). In addition to the immediate discontinuation of antipsychotic drugs is essential to use general supportive measures and symptomatic treatment.
There may be dysmotility, especially in the first few days after an injection and in the early stages of treatment. In most cases these side effects are controlled by reducing the dose and / or antiparkinsonian drugs. However, the routine use of anti-Parkinsonian agents for the prevention of side effects is not recommended.
Tardive dyskinesia may occasionally occur in patients receiving long-term treatment. Anti-Parkinsonian drugs do not reduce its manifestations and even able to aggravate the condition. Recommended dose reduction or, if possible, discontinuation of treatment.
In persistent akathisia may be useful benzodiazepines or propranolol.
You may experience insomnia (transient) and anxiety, especially if patients previously taking antipsychotics, sedative effect.
There are few reports about the development of minor transient changes functional liver samples indicators.
when receiving flupenthixol also been reported the following side effects that occur when taking other antipsychotics: in rare cases, lengthening the interval what does is winstrol legal do, ventricular (ventricular) arrhythmias – ventricular fibrillation, ventricular tachycardia, the development of paroxysmal ventricular tachycardia (Torsade de Pointes) and sudden death.
Symptoms. Drowsiness, coma, extrapyramidal symptoms, convulsions, shock, hyperthermia / hypothermia.
When concomitantly with drugs that affect the heart activity were recorded changes, lengthening the interval , development paroxysms of ventricular tachycardia , stopping heart, ventricular arrhythmia.
Treatment. Symptomatic and supportive. Measures should be taken, aimed at maintaining the activity of the respiratory and cardiovascular systems. Do not use epinephrine (adrenaline), as this can lead to a subsequent decrease in blood pressure. Seizures can be cut short with diazepam and extrapyramidal symptoms biperidenom.
Interaction with other drugs
Flyuanksol may enhance the sedative effects of alcohol, barbiturates and other depressants substances.
Flyuanksol should not be given together with guanethidine or similarly acting drugs because of possible weakening of hypotensive effect of these agents.
Concomitant use of neuroleptics and lithium increases the risk of neurotoxicity.
Tricyclic antidepressants and neuroleptics mutually inhibit the metabolism of each other.
Flyuanksol may reduce the effect of levodopa and the effect of adrenergic drugs, and the combination with metoclopramide and piperazine increases the risk of extrapyramidal disorders.
Increased what does winstrol do interval, which is characteristic for the treatment of antipsychotic drugs can be enhanced while taking drugs, prolonging interval: antiarrhythmic drugsclass (quinidine, amiodarone, sotalol, dofetilide), certain antipsychotics (thioridazine), certain antibiotics, macrolides (erythromycin) and antibiotics quinolone series (gatifloxacin, moxifloxacin), some antihistamines (terfenadine , astemizole) and cisapride, lithium and other drugs that increase interval. Avoid simultaneous reception and the above-mentioned drugs.
should be used with caution in conjunction with drugs that cause electrolyte disturbances (thiazide and thiazide diuretics), and drugs able to increase the concentration of flupenthixol decanoate in plasma, due to a possible increased risk interval prolongation and the occurrence of life-threatening arrhythmias.
Flyuanksol should not be confused with the deposited forms based on sesame oil, as this can have a significant effect on the pharmacokinetics of administered drugs.
With concomitant treatment of diabetes appointment may require dose adjustment of insulin.
If the patient previously treated with neuroleptics or tranquillizers with sedative effect, their reception should be stopped gradually.
When long-term therapy, especially with the use of large doses of what does winstrol do, necessary to carry out careful monitoring and periodic assessment of patients.
during pregnancy Flyuanksol should be used only if the expected benefit to the mother outweighs the potential risk to the fetus.
neonates whose mothers had taken antipsychotics during the last trimester of pregnancy or during labor, may show signs of intoxication such as lethargy, tremor and excessive excitability. In addition, these neonates there is a low Apgar score.
During treatment allowed breastfeeding, if deemed clinically necessary. However, it is recommended to observe the condition of the newborn, particularly in the first 4 weeks after birth.
The period of treatment should