The drug is completely and rapidly absorbed after oral administration, subjected to biotransformation in the liver. The main metabolite, found in plasma, the maximum concentration is achieved after 2 hours is biologically active a-hydroxylated derivative (2-oksiflutamid). 9496% flutamide and 92-94% a-hydroxylated metabolite binds to proteins. Because the body the drug is derived mainly kidneys, about 4.2% is excreted in the feces within 72 hours. The half-life of the active metabolite in the plasma is about 6 hours (in elderly patients – 8 hours after a single dose and 9.6 hours at a stable concentration). Following multiple oral buy winstrol administration of 250 mg of flutamide 3 times per day stable level concentrations of drug and active metabolite in the plasma was achieved following the fourth dose flutamide.

Indications for use .
Treatment of metastatic prostate cancer, when shown the suppression of testosterone action:

 

  • at the beginning of treatment in combination agonists;
  • as a supplementary treatment of patients already receiving  agonist therapy;
  • patients with surgical castration;
  • Treatment of patients with other types of hormone therapy were ineffective or intolerance to such therapy.

 

Contraindications

– Hypersensitivity to flutamide or any other component of the drug.
– Severe hepatic impairment

Precautions
In patients with decreased hepatic function, with a tendency to thrombosis and cardiovascular diseases, as well as conditions predisposing to the toxic aniline buy steroids online (one of the metabolites of flutamide – metilanilinovoe derivative): deficiency of glucose-6-phosphate dehydrogenase deficiency, smoking, haemoglobinopathies (M-hemoglobin).

Dosing and Administration
Inside, 250 mg 3 times a day every 8 hours. In the case of achieving the positive effect of the drug is applied to the signs of the progression of a tumor disease.

In the case of co-therapy buy winstrol agonists, both drugs may be administered simultaneously or reception Flutapleksa begin three days before  agonist.

In applying the drug in monotherapy
most often: gynecomastia and / or pain in the breast, sometimes accompanied by galactorrhea. These effects disappear after treatment discontinuation or dose reduction.

Less frequently: diarrhea, nausea, vomiting, increased appetite, insomnia, fatigue, tranzitornos abnormal liver function, hepatitis.

Rare: hepatitis or jaundice (including cholestatic), hepatic necrosis, hepatic encephalopathy, increased transaminase activity (these side effects are usually reversible upon discontinuation of therapy, however, there were reports of deaths due uk steroids to severe hepatic failure in the treatment of flutamide); subcutaneous hemorrhage, herpes zoster, pruritus, lupus-like syndrome; anorexia, heartburn, constipation, dyspepsia; decreased libido, headache, “tides” (sensation of heat, excessive sweating), increased blood pressure, dizziness, weakness, poor visual acuity, thirst, pain fudnoy cell swelling (fingers, feet, legs), anxiety, depression and thrombocytopenia . Prolonged treatment observed suppression of spermatogenesis. We noted some cases of hemolytic anemia, macrocytic anemia, methemoglobinemia, photosensitivity reaction, increased (including erythema, skin ulceration, bullous rash, epidermal necrolysis). Sometimes patients have changes in urine color from amber to yellow-green.

In the treatment in combination  agonists
The most common “hot flashes” (a sense of warmth, sweating), loss of libido, impotence, diarrhea, nausea, vomiting. The incidence of these side effects, except for diarrhea (more pronounced when used in combination with flutamide), the same as with buy winstrol agonist monotherapy.

Less frequently: gynecomastia, anemia, leukopenia, thrombocytopenia, anorexia, edema, symptoms of neuromuscular disorders, difficulty urinating, increased blood pressure and side effects of the central nervous system (drowsiness, depression, confusion, anxiety, neurosis).

Rare: respiratory failure, liver failure, hepatitis, cholestatic jaundice, hepatic necrosis, hepatic encephalopathy, increased light sensitivity, methemoglobinemia.

Overdose
In case of overdose, if the patient is conscious and without spontaneous vomiting, induce vomiting. It is necessary to apply symptomatic therapy with continuous monitoring of patients, and vital functions.

Interactions with other drugs
Because of the possible increase in the anticoagulant action of warfarin, while the use and Flutapleksa, anticoagulant dose should be adjusted under the control of prothrombin time.

Cautions
Flutapleksom Treatment should be under the control buy oral steriods of serum levels of liver enzymes (appropriate laboratory tests should be performed 1 time per month during the first 4 months and then on a regular basis).

In the case of liver enzymes increase 2-3 times in comparison with the upper limit of the normal range and / or jaundice in the absence of liver metastases buy winstrol application should stop.

Patients should receive the recommendation to immediately consult a doctor when the first symptoms of liver problems such as itchy skin, dark urine, nausea, vomiting, persistent loss of appetite, yellowing of the skin or whites of the eyes, pain in the right upper quadrant, or flu-like symptoms.

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