There are no adequate and well-controlled trials of fluconazole in pregnant women have been conducted.
There is currently no evidence of the effect of low doses of fluconazole (150 mg once daily for the treatment of vulvovaginalyyugo candidiasis) to increase the frequency of adverse pregnancy outcomes, as well as the relationship with the occurrence of any specific defects in the child’s development .
at high doses (400-800 mg / day) of fluconazole described several cases of multiple congenital defects in newborns whose mothers during most or all of the first trimester of receiving fluconazole therapy.
Use of the drug in pregnant women is inappropriate, except in severe or life-threatening forms fungal infections, if the expected benefit to the mother outweighs the potential risk to the fetus.
Women of childbearing age must use contraception.
Fluconazole is in the breast milk in the same anavar vs winstrol concentration as in plasma, so his appointment is contraindicated during lactation.
Dosing and Administration
Adults with cryptococcal meningitis and cryptococcal infections at other sites on the first day is usually prescribed 400 mg (8 capsules of 50 mg), and then continue treatment at a dose of 200-400 mg 1 time / day. The duration of treatment for cryptococcal infections depends on the clinical efficacy, confirmed by mycological examination; cryptococcal meningitis it is usually continued for at least 6-8 weeks. For the prevention of relapse of cryptococcal meningitis in patients , after the completion of a full course of primary therapy, fluconazole administered at a dose of 200 mg / day for a long period of time. When candidemia, disseminated candidiasis and other invasive Candida infections dose is usually 400 mg in the first day, and then – 200 mg. When insufficient clinical efficacy of the dose can be increased to 400 mg / day. The duration of therapy depends on clinical efficacy. In oropharyngeal candidiasis drug is usually administered 50-100 mg 1 time / day; Duration anavar vs winstrol of treatment – 7-14 days. If necessary, in patients with a severely reduced immune treatment may be longer. If atrophic oral candidiasis associated with wearing dentures, fluconazole is usually prescribed 50 mg 1 times / day for 14 days in combination with a local antiseptic for the treatment of prosthetic . In other locales candidiasis (except genital candidiasis), such as oesophagitis, noninvasive bronchopulmonary lesions, candiduria, candidiasis of the skin and mucous membranes, etc., the effective dose is usually 50-100 mg / day when the duration of treatment 14-30 days .
Some patients may require more frequent application.
When balanitis caused of Candida, fluconazole administered a single dose of 150 mg orally.
For the prevention of candidiasis recommended dose of fluconazole is 50-400 mg 1 time / day, depending on the degree of risk of fungal infection. If you have a high risk of generalized infection, eg in patients with severe or long-anticipated persistent neutropenia, the recommended dose is 400 mg 1 time / day. Fluconazole is administered a few days before the expected occurrence of neutropenia; after increasing the number of neutrophils over 1000 / mm3, treatment was continued for 7 days.
At mycosis of the skin, including tinea pedis, groin skin, and skin candidosis recommended dose is one 150 mg weekly or 50 mg 1 time / day. Duration of therapy in ordinary cases is 2-4 weeks, but with athlete’s foot may require a more prolonged treatment (up to 6 weeks). When pityriasis versicolor – 300 mg 1 time per week for 2 weeks, some patients required a third dose of 300 mg per week , while in some cases it is sufficient single dose of 300-400 mg; Alternative treatment scheme is the use of 50 mg 1 time a day for 2-4 weeks. When onychomycosis the recommended dose is 150 mg 1 time per week.
Treatment anavar vs winstrol should be continued until the replacement of the infected nail (uninfected nail sprouting). For the re-growth of nails on the fingers and feet normally required 3-6 months and 6-12 months, respectively. In deep endemic mycoses may require use of the drug at a dose of 200-400 mg / day for up to 2 years. The duration of therapy is determined individually; it can be 11-24 months with coccidioidomycosis; 2-17 months in paracoccidioidomycosis; Sporotrichosis 1-16 months at 3-17 months and at histoplasmosis. In children, as well as with similar infections in adults, the duration of treatment depends on the clinical and mycological effect. In children, the drug should not be applied in a daily dose that would be higher than that of adults. The drug is used every day 1 time / day. Ifcandidiasis mucous membranes of the recommended dose of fluconazole is 3 mg / kg / day. The first day can be assigned to a loading dose of 6 mg / kg in order to more quickly achieve constant equilibrium concentrations. For the treatment of generalized candidiasis and cryptococcal infections the recommended dose is 6-12 mg / kg / day, depending on the severity of the disease. For the prevention of fungal infections in children immunocompromised, in whom the risk of infection associated with neutropenia, developing as a result of tsitotok-classical chemotherapy or radiation therapy, the drug is prescribed for 3-12 mg / kg / day, depending on the severity and duration of preservation-induced neutropenia, the maximum daily dose should not more than 600 mg. in children with impaired renal function the daily dose should be reduced (in the same proportion as in adults), in accordance with the severity of renal failure. in elderly patients without renal dysfunction should follow the usual dose regimen the drug. Use of the drug in patients with impaired renal function. For a single administration of a dose change is required. Repeated appointment of the drug in creatinine clearance anavar vs winstrol more than 50 ml / min is used the usual dose of the drug, from 11 to 50 mL / min should first enter a loading dose of 50 mg to 400 mg, then applied a dose equal to 50% of the recommended. Patients regularly on dialysis one dose is applied after each hemodialysis session.