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There are no adequate and well-controlled trials of fluconazole in pregnant women have been conducted. There is currently no evidence of the effect of low doses of fluconazole (150 mg once daily for the treatment of vulvovaginalyyugo candidiasis) to increase the frequency of adverse pregnancy outcomes, as well as the relationship with the occurrence of … [Read more…]
After oral administration fluconazole is well absorbed, bioavailability – 90%. The maximum concentration after oral administration, fasted 150 mg of 90% in the content. plasma winny cycle administered intravenously in a dose of 2.5-3.5 mg / l. Simultaneous food intake has no effect on the absorption of the drug taken orally. Plasma concentration reaches its … [Read more…]
The incidence of side effects and their severity are most pronounced at the beginning of treatment, reduced to the extent of continued therapy. From the nervous system: extrapyramidal disorder, parkinsonism, tremor, akathisia, dystonia, dyskinesia, speech disorder; Infrequent – dizziness, rarely – tardive dystonia. From the mental activity: depression, insomnia, agitation; rare – aggression. On the … [Read more…]
After injection, the undergoes enzymatic cleavage into the active component is winny steroid and decanoic acid. The apparent volume of distribution. Binding to plasma proteins is approximately 99%. The maximum concentration serum reached the end of the first week after insertion. Serum concentration decreases exponentially with a half-life of approximately three weeks, reflecting the release … [Read more…]